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All of these various therapeutic options are used in an effort to avoid the need for surgery and address complications associated with IBD.Since there is no cure for IBD, current treatment goals according to the Crohn’s and Colitis Foundation of America are to induce remission, maintain remission by preventing flare-ups, and improve overall quality of life .The UC patients reported resolution of symptoms such as rectal bleeding, urgency, and/or nocturnal incontinence.The CD patients reported weight improvements, other therapy reductions, and/or decrease ileostomy output and creatinine levels.Biologics are the newest option for IBD treatment and work by targeting and suppressing TNF-α or by binding to integrin α4β7 in order to reduce inflammation [6,7].
Ulcerative colitis is a disease of unknown etiology that produces chronic inflammation of the colon, whereas CD is relapsing inflammatory condition affecting any part of the gastrointestinal tract.
Methods: In a clinical practice setting, we retrospectively evaluated seven ulcerative colitis (UC) and Crohn’s disease (CD) patients who incorporated SBI into their therapeutic regimens.
All patients previously failed to adequately respond to conventional drug therapies.
Visit for more related articles at Journal of Gastrointestinal & Digestive System 50% Ig G and ~60% total immunoglobulins, has a multifaceted mechanism of action binding microbial components, maintaining gastrointestinal immune balance, managing gut barrier function and improving nutrient utilization.
IBD animal models and a human refractory case study demonstrated that SBI can attenuate both inflammatory biomarkers and histological parameters in the bowel.